ANAZOL 125 Suspension

What is ANAZOL 125

ANAZOL 125 Suspension is an oral liquid formulation containing Metronidazole, a synthetic nitroimidazole antimicrobial agent. It is primarily used to treat infections caused by anaerobic bacteria and certain protozoa. This medication is particularly suited for pediatric patients or adults who have difficulty swallowing tablets. ANAZOL 125 offers a palatable and easy-to-administer option for treating gastrointestinal, urogenital, and systemic infections.

• Generic Name: Metronidazole
• Form: Oral Suspension
• Strength: 125 mg per 5 ml
• Uses: Treatment of amoebiasis, giardiasis, trichomoniasis, bacterial vaginosis, and anaerobic bacterial infections.

This formulation ensures precise dosing, particularly important in pediatric populations, making ANAZOL 125 a critical option in both outpatient and inpatient settings.

How to use ANAZOL 125

Correct usage of ANAZOL 125 Suspension is vital for achieving optimal therapeutic outcomes and minimizing the development of resistance or side effects:

• Shake Well: Always shake the bottle thoroughly before each use to ensure uniform distribution of the active ingredient.
• Measuring Dose: Use the provided measuring spoon, cup, or oral syringe for accurate dosing — never guess or use household spoons.
• Administration: Can be taken with or without food. Taking it with food may help reduce gastrointestinal upset.
• Schedule: Administer the doses at evenly spaced intervals to maintain a constant level of medicine in the bloodstream.
• Course Completion: Even if symptoms improve, complete the full prescribed course to prevent recurrence or resistance.
• Missed Dose: If a dose is missed, take it as soon as remembered unless it is almost time for the next scheduled dose. Do not double doses.

Close adherence to the prescribed dosing regimen enhances the effectiveness of treatment and ensures complete eradication of the infection.

Mode of Action ANAZOL 125

Metronidazole, the active ingredient in ANAZOL 125, exerts its effects through a unique mechanism:

• Penetration: Enters the microbial cells of anaerobic bacteria and protozoa via passive diffusion.
• Activation: Inside the cell, the nitro group of metronidazole is reduced by electron transport proteins, producing reactive metabolites.
• DNA Disruption: These metabolites interact with DNA, causing strand breakage, inhibiting nucleic acid synthesis, and ultimately leading to cell death.
• Selective Toxicity: Metronidazole selectively targets anaerobes and protozoa because the reduction process occurs only in low-oxygen environments typical of these pathogens.

Thanks to its targeted action, Metronidazole is highly effective against infections where oxygen levels are minimal, such as deep tissue infections and intra-abdominal infections.

ANAZOL 125 Interactions ANAZOL 125

ANAZOL 125 (Metronidazole) can interact with several other drugs, which may alter its effect or increase side effect risks:

• Alcohol: Consumption during therapy can cause a disulfiram-like reaction, leading to nausea, vomiting, flushing, and tachycardia.
• Warfarin and Anticoagulants: May potentiate the anticoagulant effect, increasing bleeding risks. Monitor INR closely.
• Phenytoin and Phenobarbital: May increase the metabolism of metronidazole, reducing its efficacy.
• Disulfiram: Concurrent use can cause acute psychotic reactions — avoid combination.
• Lithium: Metronidazole may elevate lithium levels, necessitating close monitoring of lithium toxicity signs.

Always provide a full list of current medications and supplements to your healthcare provider before starting ANAZOL 125 Suspension to avoid serious interactions.

Dosage of ANAZOL 125

Dosage of ANAZOL 125 must be individualized based on the infection type, patient's age, weight, and medical condition:

• Amoebiasis:
  • Children: 35-50 mg/kg/day divided into three doses for 10 days.
• Giardiasis:
  • Children: 15-40 mg/kg/day divided into two or three doses for 5-7 days.
• Anaerobic Infections:
  • Children: 22.5-40 mg/kg/day in divided doses every 8 hours.

Dosing must be strictly adhered to, and adjustments may be needed for patients with liver impairment or concurrent medical conditions. Consult your healthcare provider for personalized dosage recommendations.

Possible side effects of ANAZOL 125

Although generally well-tolerated, ANAZOL 125 can cause side effects in some individuals:

• Gastrointestinal: Nausea, metallic taste, dry mouth, vomiting, and abdominal discomfort are common.
• Neurological: Headache, dizziness, and rarely, seizures or peripheral neuropathy with long-term use.
• Allergic Reactions: Rash, itching, or swelling especially of the face, tongue, or throat; severe reactions are rare but require immediate attention.
• Hematologic: Rare cases of reversible neutropenia and thrombocytopenia.
• Urinary: Darkening of the urine, which is harmless but may alarm patients if not forewarned.

Most side effects are mild and transient; however, report any persistent or severe reactions to a healthcare provider promptly.

Contraindications of ANAZOL 125 Suspension

ANAZOL 125 should not be used in certain circumstances where the risks outweigh the benefits:

• Hypersensitivity: Known allergy to metronidazole or other nitroimidazole derivatives.
• Pregnancy: Particularly contraindicated during the first trimester unless absolutely necessary.
• Neurological Disorders: Patients with active central nervous system diseases such as epilepsy should use with extreme caution.
• Alcohol Use: Concurrent alcohol consumption is contraindicated due to risk of severe adverse reactions.

Proper evaluation and a detailed medical history must precede the initiation of ANAZOL 125 therapy to avoid complications.

Storage of ANAZOL 125 Suspension

Proper storage conditions ensure the stability and effectiveness of ANAZOL 125:

• Temperature: Store below 25°C (77°F). Do not freeze.
• Protection: Keep the bottle tightly closed and protect it from direct light and moisture.
• Shelf Life: Check the expiry date on the bottle. Discard any unused portion after the treatment course is completed or after the expiry date.
• Child Safety: Keep the bottle out of the reach of children to prevent accidental ingestion.

Following storage guidelines preserves the medicine's efficacy and protects patient safety throughout the course of treatment.

Although generally well-tolerated, ANAZOL 125 can cause side effects in some individuals:

• Gastrointestinal: Nausea, metallic taste, dry mouth, vomiting, and abdominal discomfort are common.
• Neurological: Headache, dizziness, and rarely, seizures or peripheral neuropathy with long-term use.
• Allergic Reactions: Rash, itching, or swelling especially of the face, tongue, or throat; severe reactions are rare but require immediate attention.
• Hematologic: Rare cases of reversible neutropenia and thrombocytopenia.
• Urinary: Darkening of the urine, which is harmless but may alarm patients if not forewarned.

Most side effects are mild and transient; however, report any persistent or severe reactions to a healthcare provider promptly.

ANAZOL 125 Contraindications ANAZOL 125

ANAZOL 125 should not be used in certain circumstances where the risks outweigh the benefits:

• Hypersensitivity: Known allergy to metronidazole or other nitroimidazole derivatives.
• Pregnancy: Particularly contraindicated during the first trimester unless absolutely necessary.
• Neurological Disorders: Patients with active central nervous system diseases such as epilepsy should use with extreme caution.
• Alcohol Use: Concurrent alcohol consumption is contraindicated due to risk of severe adverse reactions.

Proper evaluation and a detailed medical history must precede the initiation of ANAZOL 125 therapy to avoid complications.

Storage of ANAZOL 125

Proper storage conditions ensure the stability and effectiveness of ANAZOL 125:

• Temperature: Store below 25°C (77°F). Do not freeze.
• Protection: Keep the bottle tightly closed and protect it from direct light and moisture.
• Shelf Life: Check the expiry date on the bottle. Discard any unused portion after the treatment course is completed or after the expiry date.
• Child Safety: Keep the bottle out of the reach of children to prevent accidental ingestion.

Following storage guidelines preserves the medicine's efficacy and protects patient safety throughout the course of treatment.